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The Cancer Void

The Cancer Void: Tumor Progression as D1→D2→D3 Cascade and the Fantasia Bound in Molecular Immunology

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Opacity3/3███
Responsiveness3/3███
Coupling3/3███
Void Index9/12D3-Complete
Péclet NumberPe=43.9Phase IV

The Cancer Void: Tumor Progression as D1→D2→D3 Cascade and the Fantasia Bound in Molecular Immunology

Paper 43 — The Cancer Void · v1.0 · February 2026

Establishes cancer as a D3 biological substrate through void-thermodynamic analysis, mapping oncogenesis→immune evasion→metastasis to the D1→D2→D3 drift cascade. Derives the V=9 necessity theorem for D3-complete tumors, interprets the Warburg effect as thermodynamic engagement-drive maximization, and proves combination therapy superiority via the engagement-transparency conjugacy bound I(D;Y)+I(M;Y)≤H(Y). Validates the Fantasia Bound on HIV CTL escape data (Asquith et al. 2006, N=10 cohort groups, Spearman=0.97).

Platform Scores — Cancer Biology

Void index across 10 platforms, scored on the three-dimension framework (0–12).

Platform Score Void Load
Glioblastoma (GBM) 9/12
Pancreatic ductal 9/12
Triple neg. breast 8/12
Melanoma (advanced) 7/12
NSCLC (stage IV) 7/12
Ovarian serous 6/12
AML 6/12
Colorectal MSS 5/12
CLL (indolent) 4/12
Hodgkin lymphoma 3/12

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Complete methodology, empirical data, falsifiable predictions, and kill conditions.

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Paper 43 · v1.0 · February 2026 · CC-BY 4.0 · 10.5281/zenodo.18737180